Anticardiolipin antibodies and Lupus anticoagulant; prevalence in pregnant patients with recurrent miscarriages
DOI:
https://doi.org/10.47672/ajhmn.928Keywords:
Recurrent miscarriages, antiphospholipid syndrome, anticardiolipin antibodies. Lupus anticoagulant.Abstract
Objective: Evaluation of the frequency of anticardiolipin antibodies and lupus anticoagulant levels in women with histories of three or more first trimester recurrent miscarriages.
Methodology: It was a descriptive case series carried out at private clinical practice in Peshawar. About 86 patients were enrolled in the study. They had three or more first trimester recurrent abortions. Pregnant patients between ages 22 and 35 years were included. Any patient diagnosed with other etiologies of recurrent miscarriages was excluded. Percentages and frequencies were used to analyze the data.
Results: Mean age of pregnant patients was 28.4(±3.25) years. Mean number of miscarriages was 3.5. High anticardiolipin antibodies were detected in 23.3% of pregnant patients. There was no pronounced difference regarding high levels of IgG and IgM. No case of raised lupus anticoagulant was found.
Conclusion: Pregnant patients who experience recurrent miscarriages show higher prevalence of antibodies of anticardiolipin type. It is recommended that all such cases should be subjected to APS screening.
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