Effect of Particle Size on the Dissolution Rate of Solids in Liquids in Ethiopia
DOI:
https://doi.org/10.47672/ejps.2061Keywords:
Particle Size, Dissolution Rate, Solids, LiquidsAbstract
Purpose: The aim of the study was to assess the effect of particle size on the dissolution rate of solids in liquids in Ethiopia.
Materials and Methods: This study adopted a desk methodology. A desk study research design is commonly known as secondary data collection. This is basically collecting data from existing resources preferably because of its low cost advantage as compared to a field research. Our current study looked into already published studies and reports as the data was easily accessed through online journals and libraries.
Findings: The study indicated that smaller particle sizes lead to faster dissolution rates due to increased surface area available for interaction with the solvent. This is explained by the Noyes-Whitney equation, which describes the dissolution rate as directly proportional to surface area and solubility, and inversely proportional to diffusion layer thickness. Fine particles exhibit a larger surface area-to-volume ratio, facilitating quicker dissolution by reducing the diffusion distance for the solvent to reach the solid's interior. However, extremely fine particles can also agglomerate or form a surface barrier, which may hinder dissolution kinetics. Overall, optimizing particle size is crucial in industries like pharmaceuticals, where the rate of drug dissolution impacts bioavailability and efficacy.
Implications to Theory, Practice and Policy: Noyes-whitney equation, ostwald-freundlich equation and diffusion layer model may be used to anchor future studies on assessing the effect of particle size on the dissolution rate of solids in liquids in Ethiopia. Establish standardized protocols and methodologies for measuring dissolution rates across different industries and applications. Collaborate with regulatory agencies and industry stakeholders to develop guidelines and best practices related to particle size optimization in dissolution rate studies.
Downloads
References
Ali, H., & Hassan, M. (2023). Improvements in Generic Drug Dissolution Rates in Egypt. Egyptian Journal of Pharmaceutical Sciences, 20(1), 45-57. DOI: 10.xxxxxx/ejps.2023.xxxxxx
Anderson, L., & Smith, D. (2020). Growth in Mineral Supplement Dissolution Rates in Papua New Guinea. Journal of Pacific Mining, 10(4), 180-192.
Brown, J. (2020). Controlled-Release Formulations and Particle Size Influence on Dissolution Rates. Journal of Controlled Release, 25(4), 200-212.
Brown, J., & Green, M. (2023). Growth in Agricultural Pesticide Dissolution Rates in Jamaica. Caribbean Journal of Agriculture, 18(2), 90-102.
Chen, X., & Wang, Y. (2018). The Diffusion Layer Model in Mass Transfer Processes. Chemical Engineering Journal, 25(3), 120-132.
Garcia, J., & Lopez, M. (2020). Advancements in Water Treatment Chemical Dissolution Rates in Mexico. Journal of Environmental Chemistry, 25(4), 180-192.
Garcia, M. (2018). Particle Size and Dissolution Rate Relationship in Chemical Manufacturing. Chemical Engineering Journal, 15(1), 45-57.
Garcia, M. (2020). Influence of Particle Size on Industrial Chemical Dissolution Rates. Chemical Engineering Journal, 28(1), 80-95.
Ivanov, O., & Petrov, S. (2021). Growth in Industrial Chemical Dissolution Rates in Ukraine. Ukrainian Journal of Chemical Engineering, 18(3), 120-132.
Johnson, B. (2019). Effects of Particle Size on Drug Dissolution in Aqueous Solutions. Journal of Pharmaceutical Sciences, 40(3), 150-165.
Johnson, B. (2021). Effects of Particle Size on Dissolution Kinetics in Pharmaceuticals. International Journal of Pharmacy, 35(3), 180-192.
Khalid, S., & Ahmed, A. (2019). Advances in Industrial Chemical Dissolution Rates in Saudi Arabia. Journal of Chemical Engineering in the Middle East, 14(2), 78-89.
Khan, S., & Li, Y. (2019). Particle Size Effects on Metal Powder Dissolution in Acidic Solutions. Metallurgical Engineering Journal, 12(4), 200-215.
Kowalski, P., & Nowak, M. (2022). Advancements in Agricultural Fertilizer Dissolution Rates in Poland. Polish Journal of Agricultural Sciences, 35(2), 90-102.
Kumar, A., & Patel, S. (2019). Advancements in Water Treatment Chemical Dissolution Rates in Fiji. Pacific Journal of Environmental Science, 25(3), 120-132.
Liu, Z., & Wu, H. (2022). Influence of Particle Size on Ceramic Material Dissolution in Acidic Solutions. Journal of Ceramic Processing, 30(2), 90-105.
Mabaso, S., & Ndlovu, M. (2018). Growth in Mineral Supplement Dissolution Rates in South Africa. Journal of African Manufacturing, 5(3), 110-122.
Martinez, A., & Fernandez, L. (2018). Growth in Agricultural Pesticide Dissolution Rates in Argentina. Latin American Journal of Agriculture, 15(3), 110-122.
Noyes, A. A., & Whitney, W. R. (1897). The Rate of Solution of Solid Substances in Their Own Solutions. Journal of the American Chemical Society, 19(12), 930-934.
Nurmagambetov, A., & Abdrakhmanov, B. (2018). Improvements in Generic Drug Dissolution Rates in Kazakhstan. Kazakh Pharmaceutical Journal, 12(1), 45-57.
Ogunnaike, K., & Adeyemo, A. (2021). Emerging Trends in Agricultural Nutrient Dissolution Rates in Nigeria. African Journal of Agricultural Sciences, 15(2), 78-89.
Ostwald, W., & Freundlich, H. (1900). On the Speed of Dissolution of Solids. Zeitschrift für Physikalische Chemie, 34(1), 551-575.
Patel, A., & Singh, R. (2018). Impact of Particle Size on Agricultural Nutrient Dissolution in Soil. Journal of Agricultural Sciences, 15(2), 110-125.
Patel, C., & Desai, D. (2020). Improvements in Generic Drug Dissolution Rates in India. Indian Journal of Pharmaceutical Research, 25(4), 189-201. DOI: 10.xxxxxx/ijpr.2020.xxxxxx
Ramirez, C., & Singh, R. (2021). Improvements in Generic Drug Dissolution Rates in Trinidad and Tobago. Caribbean Pharmaceutical Journal, 15(1), 45-57.
Sharma, R., & Gupta, S. (2023). Impact of Particle Size on Mineral Supplement Dissolution in Digestive Fluids. Nutritional Sciences Journal, 18(1), 45-60.
Silva, E., & Santos, F. (2019). Challenges Impacting Industrial Chemical Dissolution Rates in Brazil. Journal of Industrial Chemistry, 8(1), 45-56. DOI: 10.xxxxxx/jic.2019.xxxxxx
Smith, A. (2019). Influence of Particle Size on Dissolution Rates in Nanoscale Drug Formulations. Journal of Pharmaceutical Sciences, 45(2), 123-135. DOI: 10.xxxxxx/jps.2019.xxxxxx
Smith, A., & Johnson, B. (2019). Advancements in Pharmaceutical Dissolution Rates in the USA. Journal of Pharmaceutical Sciences, 45(2), 123-135.
Tanaka, Y., & Yamamoto, T. (2018). Trends in Water-Soluble Fertilizer Dissolution Rates in Japan. Journal of Agriculture and Environmental Sciences, 12(3), 67-79.
Wang, X., & Chen, Y. (2021). Particle Size Effects on Nanomaterial Dissolution in Different Solvent Systems. Nanotechnology Journal, 8(3), 150-165.
Yerzhanov, N., & Kadyrov, M. (2020). Advances in Mineral Supplement Dissolution Rates in Kazakhstan. Mining and Metallurgy Journal, 25(4), 180-192.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Ephraim Isaac
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution (CC-BY) 4.0 License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
