Serum Cortisol and Glucose Indices Following Rumenotomy in West African Dwarf Goats Premedicated with Xylazine or Diazepam and Inducted with Propofol
DOI:
https://doi.org/10.47672/ejah.1651Keywords:
Cortisol, Glucose, Xylazine, Diazepam, PropofolAbstract
Purpose: Anaesthesia was induced in West African Dwarf (WAD) goats using Propofol and a combination of different sedatives, propofol (P), xylazine (X), Propofol (P), and Diazepam (D) and control Propofol (P) and the effects of rumenotomy on cortisol and glucose of West African dwarf goats were determined.
Methodology: Twelve (WAD) goats were randomly assigned to three treatment groups tagged A, B, and C. Rumenotomy was carried out on these animals, premedicated with Xylazine or Diazepam and anaesthetized with Propofol, and data was presented in charts and as (Mean ± SEM).
Findings: Cortisol concentration showed no statistical (P > 0.05) difference in group C pre-surgery (14.55 ± 1.34 mg/dL) and up to 96 hours post-rumenotomy (13.45 ± 0.68 mg/dL). In groups A and B, cortisol concentration significantly (P < 0.05) increased from pre-surgical value (14.40 ± 1.27; 13.68 ± 1.22 mg/dL) reaching a peak at 24 hours post-rumenotomy (68.85 ± 3.41; 46.63 ± 5.86mg/dL) followed by a significant (P < 0.05) decrease at 96 hours post-rumenotomy (33.46 ± 3.58; 13.80 ± 2.65 mg/dL), but these were statistically (P < 0.05) higher in group A compared to group B. The glucose concentration was statistically (P < 0.05) increased in group A (72.50 ± 3.30; 75.25 ± 5.02 g/dL) compared to groups B (65.50 ± 4.50; 65.50 ± 1.71 g/dL) and C (55.50 ± 2.87; 62.25 ± 8.84 g/dL) at intra-surgery and immediate post-surgery. From 24 and up to 96 hours post-rumenotomy, no statistical difference existed for the glucose concentration in all groups of goats.
Conclusion: The Cortisol and glucose indices increased across the groups which showed that the animals experienced stress during the procedure.
Recommendations: The Cortisol and Glucose indices following rumenotomy showed that the Diazepam-Propofol combination (group B) is preferred because it caused less stress and gave a good plane of anaesthesia in West African Dwarf goats.
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References
Beerda B, Schilder, M.B, & van Hooff J. (1997). Manifestation of chronic and acute stress in dogs. Applied Animal Behavioral Science. 52:307-319
Broom, D.M (2000). Welfare assessment and welfare problem areas during handling and transport. In: Livestock Handling and Transport. (Eds.). T Grandin, CABI Publishing, New York, USA, pp. 43-61.
Burton, D Grainne, N, & George, H. (2004). Endocrine and metabolic response to surgery Continuing Education Anaesthesia Critical Care, 4 (5) pp. 144-147.
Carey DP, Manas K, Delicata RJ, & Mahadevan A. (1999) In: Response to surgical trauma. Surgical Emergencies.Monson J, Duthie G, O'Malley K, editors. USA: Blackwell Publishers. pp. 25-36.
Chen Y, Arsenault R, Napper S, & Griebel P (2015). Models and methods to investigate acute stress responses in cattle. Animals. 5:1268-1295.
Coppola CL, Grandin T, & Enns, RM. (2006). Human interaction and cortisol: can human contact reduce stress for shelter dogs? Physiology and Behaviour. 87:537-541.
Desborough JP. (2000). The stress response to trauma and surgery. British Journal of Anaesthesiology; 85(1): 109-17.
Giannoudis P, Dinopoulos H, Chalidis B, & Hall G. (2006) Surgical stress response. Injury Int. J. Care Injured. 37S:S3-S9.
Hall GM, Peerbhoy D, & Shenkin A, (2001). Relationship of the functional recovery after hip arthroplasty to the neuroendocrine and inflammatory responses. British Journal of Anaesthesia; 87(4): 537-42.
Haverbeke A, Diederich C, & Depiereux E. (2008). Cortisol and behavioral responses of working dogs to environmental challenges. Physiology and Behaviors. 93:59-67.
Horta, R.S., Figueiredo, M.S., Lavalle, G.E., Costa, M.P., Cunha, R.M. & Araújo, R.B. (2015) Surgical stress and postoperative complications related to regional and radical mastectomy in dogs. Acta Veterinary Scandiva., 57(1): 1-10.
Horvat Z, Igyarto B.Z, & Magyar A. (2007). Three different coping styles in police dogs exposed to a short-term challenge. Hormones and Behaviours. 52:621-630.
Kahn, C.M (2005). Pain management, in the Merck Veterinary Manual 9thEd. Merck and Co Inc. White house station N.J, USA, pp. 1691-1697.
Kehlet, H (1998). Modification of responses to surgery by neural blockade. Canadian Journal of Anaesthesia 48 pp 67-71.
Moberg, G. (2000). Biological response to stress: implications for animal welfare. The biology of animal stress: basic principles and implications for animal welfare: 1-21.
Mormède, P., Andanson, S. Auprin, B Beerda, B. Gumen, D,.Malmkvist, J,.Manteca, X,. Manteuffel, G,.Prunet, P,. van Reenen, C. G,.Richard, S & Veissier, I. (2007). Exploration of the hypothalamic-pituitary-adrenal function as a tool to evaluate animal welfare. Physiol. Behav. 92:317-339.
Saidu, A. M., Bokko, P. B., Mohammed, A., Bukbuk, D. N., & Igwenagu, E. (2016). Serum cortisol of Sahel goats following rumenotomy with assorted anaesthetics and sutures. International journal of veterinary science and medicine, 4(1), 23-26.
Singh M (2003). Stress response and anesthesia. Indian Journal of Anaesthesia 47(6): 427-434.
Weledji EP. (2014) Cytokines and postoperative hyperglycaemia: From claude bernard to enhanced recovery after surgery. International Journal of Surgical Research 3(1):1-6.
Yuki, K., Matsunami, E., Tazawa, K., Wang, W., DiNardo, J.A. & Koutsogiannaki, S. (2017) Pediatric perioperative stress responses and anesthesia. Perioperative. Pain Medicine., 2(1): 1-12.
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