RISK FACTORS LEADING TO MAJOR LOWER LIMB AMPUTATIONS IN DIABETIC PATIENTS WITH FOOT ULCERS

Authors

  • Kamran Hakeem Khan
  • Fazal Ghani
  • Kamran Ahmad
  • Mudassir Shahzad

DOI:

https://doi.org/10.47672/ajhmn.932
Abstract views: 238
PDF downloads: 213

Keywords:

Minor amputation, debridement, diabetic patients, foot ulcers

Abstract

Purpose: Foot ulceration in persons with diabetes is the most frequent precursor to amputation, which impairs their activities. The aim of this study was to describe factors that lead to amputation of a diabetic foot, and propose a management strategy to prevent major amputation.

Methods: Cross-sectional study was conducted at the Qazi Hussain Ahmad Hosptial, Nowshera Pakistan, from Jan, 2016, July 2021, and comprised patients of either gender having type 1 or type 2 diabetes and foot ulcers. The wounds were assessed according to Wagner wound staging and wound sepsis was evaluated in terms of local infection of the wound, leukocytosis and osteomyelitis of the bone. The glycemic control of these patients was assessed on presentation by measuring glaciated hemoglobin levels. Data was analyzed using SPSS 22.

Findings: Out Of the 450 patients, 263(60%) were males and 187(40%) were females. Majority patients 193(43%) were aged 40-70 years. All 450(100%) patients underwent some type of amputation. Of all the amputations, 301(67%) were done in patients with poor glycaemic control on presentation, and 187(41%) in those with stage 4 wound. Local wound infection, increased total leukocyte count and bone showing features of osteomyelitis were significantly associated with increased risk of lower extremity amputations (p<0.05).

Conclusion: With the proper glycemic control and early presentation and treatment, majority of amputations could be avoided in diabetic patients with foot ulcers.

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Author Biographies

Kamran Hakeem Khan

Assistant Professor, General Surgery, Qazi Hussain Ahmad Medical Complex, Nowshegra KPK, Pakistan

Fazal Ghani

Assistant Professor, General Surgery, Qazi Hussain Ahmad Medical Complex, Nowshegra KPK, Pakistan

Kamran Ahmad

Assistant Professor, General Surgery, Qazi Hussain Ahmad Medical Complex, Nowshegra KPK, Pakistan

Mudassir Shahzad

Assistant Professor, General Surgery, Qazi Hussain Ahmad Medical Complex, Nowshegra KPK, Pakistan

References

Shatnawi NJ, Al-Zoubi NA, Hawamdeh HM, Khader YS, Garaibeh K,Heis HA. Predictors of major lower limb amputation in type 2 diabetic patients referred for hospital care with diabetic foot syndrome. Diabetes Metab Syndr Obes. 2018; 11:313-9.

Shin JY, Roh SG, Lee NH, Yang KM. Influence of epidemiologic and patient behavior–related predictors on amputation rates in diabetic patients: Systematic review and meta-analysis. Int J LowExtrem Wounds. 2017; 16:14-22.

Yasin M, Zafar S, Rahman H, Khan TA, Nazir S, Shah S, et al. Baseline characteristics of infected foot ulcers in patients with diabetes at a tertiary care hospital in Pakistan. 2018; 27:S26-S32.

Smith AD, Hawkins AT, Schaumeier MJ, de Vos MS, Conte MS, Nguyen LL. Predictors of major amputation despite patent bypass grafts. J Vasc Surg. 2016; 63:1279-88.

Usman K, Khan S, Iftikhar M, Khattak TG. Glycosylated HemoglobinAs Predictor For Lower Extremity Amputation In Diabetic Patients. Gomal J Med Sci. 2017; 15:16-20.

Acar E, Kacıra BK. Predictors of lower extremity amputation andreamputation associated with the diabetic foot. J Foot Ankle Surg. 2017; 56:1218-22.

Betman MJ, Hulst I, van Dijk LC, van Overhagen H, van Eps RG, Veger HT, et al. Amputation in diabetic foot patients: a prediction model. Diabetic Foot J. 2018; 21:32-43.

Di Giovanni P, Scampoli P, Meo F, Cedrone F, D’Addezio M, Di Martino G, et al. The impact of gender on diabetes-related lower extremity amputations: An Italian regional analysis on trends and predictors. Foot Ankle Surg. 2020.

Ferreira L, Carvalho A, Carvalho R. Short-term predictors of amputation in patients with diabetic foot ulcers. Diabetes & Metabolic Syndrome: Clin Res Rev. 2018;12:875-9.

Hickson LJ, Rule AD, Thorsteinsdottir B, Shields RC, Porter IE, Fleming MD, et al. Predictors of early mortality and readmissions among dialysis patients undergoing lower extremity amputation. J Vasc Surg. 2018; 68:1505-16.

Jeong EG, Cho SS, Lee SH, Lee KM, Woo SK, Kang Y, et al. Depth and combined infection is important predictor of lower extremity amputations in hospitalized diabetic foot ulcer patients. Korean JIntern Med. 2018; 33:952-60.

Kaneko M, Fujihara K, Yamamoto M, Kitazawa M, Ishizawa M, Osawa T, et al. Incidence and Risk Factors for Amputation in Patients with Diabetes in Japan-Historical Cohort Study Using a Nationwide Claims Database. Am Diabetes Assoc; 2018; 67:11-32.

Kaplan S, Hemsinli D, Kaplan S, Arslan A. Amputation predictors in diabetic foot ulcers treated with hyperbaric oxygen. J Wound Care. 2017; 26:361-6.

Mehraj M, Shah I. A review of Wagner classification and current concepts in management of diabetic Foot. Int J Ortho Sci. 2018;

Kim JL, Shin JY, Roh SG, Chang SC, Lee NH. Predictive laboratory findings of lower extremity amputation in diabetic patients: meta- analysis. Int J Low Extrem wounds. 2017; 16:260-8.

Sayiner Z, Can F, Akarsu E. Patients’ clinical characteristics and predictors for diabetic foot amputation. Prim Care Diabetes. 2019; 13:247-51.

Kim SY, Kim TH, Choi JY, Kwon YJ, Choi DH, Kim KC, et al. Predictors for amputation in patients with diabetic foot wound. Vasc Specialist Int. 2018; 34:109-16.

Sen P, Demirdal T, Emir B. Meta‐ analysis of risk factors for amputation in diabetic foot infections. Diabetes Metab Res Rev. 2019; 35:e3165.

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Published

2022-02-21

How to Cite

Khan, K. H. ., Ghani, F. ., Ahmad, K. ., & Shahzad, M. . (2022). RISK FACTORS LEADING TO MAJOR LOWER LIMB AMPUTATIONS IN DIABETIC PATIENTS WITH FOOT ULCERS. American Journal of Health, Medicine and Nursing Practice, 7(3), 26 - 32. https://doi.org/10.47672/ajhmn.932

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