COMPARISON OF EFFICACY OF COMBINATION OF METFORMIN PLUS MODIFIED-RELEASE GLICLAZIDE WITH COMBINATION OF METFORMIN PLUS SITAGLIPTIN IN PATIENTS WITH TYPE-2 DIABETES MELLITUS

Authors

  • Atta Muhammad Khan
  • Nowsherwan
  • Muhammad Abbass
  • Amjad Ali
  • Hussain Afridi
  • Wali Gul
  • Shah zaib

DOI:

https://doi.org/10.47672/ajhmn.863

Keywords:

Efficacy, Metformin plus modified-release Gliclazide, Metformin plus Sitagliptin, type-2 diabetes mellitus.

Abstract

Introduction: Diabetes Mellitus (DM) is one of the leading causes of morbidity and mortality around the world and is responsible for 3.8 million deaths per year. Its prevalence had shown an exponential rise worldwide in the last two decades, from 30 million cases in 1985 to 177 million in 2000

Objective: To compare the efficacy of the combination of Metformin plus modified-release Gliclazide with a variety of Metformin plus Sitagliptin in patients with type-2 diabetes mellitus.

Methodology: This study was conducted at the Department of Medicine, Lady Reading Hospital Peshawar. The study design was a randomized controlled trial conducted for one year from May 2017 to May 2018, in which 62 patients in each group were observed. All patients with type 2 Diabetes Mellitus with baseline HbA1c ≥ 8% and duration >1 year, either gender with age range 35 to 65 years, were included. All patients were subjected to detailed history and clinical examinations. All patients were randomly allocated in two groups by lottery method. Patients in Group A were subjected to the combination of Metformin (1gm twice daily) with modified-release Gliclazide (60mg), and patients in Group B were subjected to the variety of Metformin (1 gm twice daily) with Sitagliptin (50 mg twice daily). All patients were followed up after three months, and blood samples for HbA1c levels were obtained. The analysis was done in SPSS version 20.

Results: The Study showed that the mean age in Group A was 58 years ± 12.78, and the mean age in Group B was 55 years ± 13.12. In Group A, 44% of patients were male, and 56% of patients were female, while in Group B, 45% of patients were male, and 55% of patients were female. Moreover, Group A (Metformin (1gm twice daily) + Gliclazide (60mg)  was effective in 45% of patients while Group B Metformin (1 gm twice daily) + Sitagliptin (50 mg twice daily) was effective in 71% of patients.

Conclusion: Our study concludes that Metformin plus Sitagliptin is more effective than Metformin plus modified-release Gliclazide.

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Author Biographies

Atta Muhammad Khan

Assistant Professor of Medicine, MTI, LRH, Peshawar, Pakistan.

Nowsherwan

Associate Professor of Medicine, M.T.H Hospital Peshawar, Pakistan.

Muhammad Abbass

Associate Professor of Medicine, MMC hospital mardan, Pakistan.

Amjad Ali

Professor of Medicine, MMC, Hospital Mardan, Pakistan.

Hussain Afridi

Assistant professor Diabetes and endocrinology HMC Hospital Peshawar, Pakistan.

Wali Gul

Consultant Medical sp DHQ hospital batkhala, Pakistan.

Shah zaib

Assistant Professor of Medicine, MMC hospital mardan, Pakistan.                  

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Published

2021-12-02

How to Cite

Khan, A. . ., Nowsherwan, N., Abbass, M. ., Ali, A. ., Afridi, H. ., Gul, W. ., & zaib, S. . (2021). COMPARISON OF EFFICACY OF COMBINATION OF METFORMIN PLUS MODIFIED-RELEASE GLICLAZIDE WITH COMBINATION OF METFORMIN PLUS SITAGLIPTIN IN PATIENTS WITH TYPE-2 DIABETES MELLITUS. American Journal of Health, Medicine and Nursing Practice, 6(5), 38–44. https://doi.org/10.47672/ajhmn.863

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