INCREASED MORTALITY ASSOCIATED WITH TREATMENT OF TYPE 2 DIABETES AMONG COVID-19 PATIENTS A SINGLE CENTER STUDY
DOI:
https://doi.org/10.47672/ajhmn.839Keywords:
Increased, mortality, associated, type 2 diabetes, covid-19 patients.Abstract
Purpose: COVID-19 caused by SARS-COV-2 infection can lead to multi-organ injuries and significant mortality in severe and critical patients, especially among those individuals with type 2 diabetes (T2D) as a comorbidity. While attenuated mortality was observed with aggressive glucose control, it was unclear whether therapeutic regimens including insulin treatment were beneficial for patients with COVID-19 and T2D. This retrospective study investigated 320 patients with COVID-19 and T2D from a cohort of 2950 cases from Wuhan, China. Unexpectedly, we found that insulin treatment for patients with COVID-19 and T2D was associated with a significant increase in mortality (23.2% versus 2.5%; adjusted HR, 5.38 [2.75-10.54]). Further analysis showed that insulin treatment was associated with enhanced systemic inflammation and aggravated injuries of vital organs. Therefore, insulin treatment for patients with COVID-19 and T2D should be used with caution.
Methodology: We performed comprehensive literature retrieval from the date of inception until February 2, 2021, in medical databases (Google scholar, Web of Science, Embase, and Cochrane Library), regarding mortality outcomes in patients with T2DM who have COVID-19. Pooled OR and 95% CI data were used to assess relationships between antidiabetic agents and mortality.
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Copyright (c) 2021 Amjad Ali, Muhammad Abbas, Nowsherwan, Atta Muhammad Khan, Hussain Afridi, Sabir rehman, Wail Gul, Iftikhar Muhammad
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