Influence of Gut Microbiota Diversity on Human Immune System Response in Korea

Authors

  • Jian Choi Ansan University

DOI:

https://doi.org/10.47672/ejb.2506

Keywords:

Gut Microbiota, Diversity, Human, Immune System Response

Abstract

Purpose: The aim of the study was to assess the influence of gut microbiota diversity on human immune system response in Korea.

Materials and Methods: This study adopted a desk methodology. A desk study research design is commonly known as secondary data collection. This is basically collecting data from existing resources preferably because of its low cost advantage as compared to a field research. Our current study looked into already published studies and reports as the data was easily accessed through online journals and libraries.

Findings: The study found that a diverse microbiota promotes immune homeostasis by enhancing the production of regulatory T cells and anti-inflammatory cytokines, which help prevent excessive immune responses and reduce the risk of autoimmune diseases. Research has shown that a lack of microbial diversity can lead to dysbiosis, which is associated with increased susceptibility to infections and inflammatory conditions like allergies, asthma, and inflammatory bowel disease. Furthermore, specific bacterial strains have been linked to the modulation of immune responses, such as the stimulation of antibody production and the maturation of immune cells. Overall, maintaining a rich and balanced gut microbiota is crucial for a well-functioning immune system and protection against pathogens.

Implications to Theory, Practice and Policy: Hygiene hypothesis, old friends hypothesis and microbiota-gut-brain axis may be used to anchor future studies on assessing the influence of gut microbiota diversity on human immune system response in Korea. Healthcare practitioners should prioritize dietary interventions that enhance gut microbiota diversity, recommending increased consumption of fiber-rich foods, fermented products, and a variety of fruits and vegetables. Policymakers should collaborate with health organizations to create comprehensive nutrition guidelines that prioritize gut health, emphasizing diverse diets rich in fiber and fermented foods to reduce the prevalence of immune-related disorders.

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References

Ahmed, S. (2022). Pro-inflammatory cytokines in active tuberculosis patients in Pakistan. Journal of Infection and Public Health, 15(4), 431-437. https://doi.org/10.1016/j.jiph.2021.12.014

Bäckhed, F. (2021). The gut microbiota as a key regulator of metabolism. Nature Reviews Microbiology, 19(2), 73-84. https://doi.org/10.1038/s41579-020-00412-7

Bashir, S. (2023). Immune responses to multidrug-resistant tuberculosis in Pakistan. Clinical Microbiology and Infection, 29(1), 95-100. https://doi.org/10.1016/j.cmi.2022.07.024

Buchan, I. E. (2022). COVID-19 and elevated cytokine levels: A study on immune activation. Journal of Inflammation Research, 15, 123-134. https://doi.org/10.2147/JIR.S348826

Chimge, D. (2023). Cytokine profiles in pneumonia: A study in Tanzanian children. International Journal of Infectious Diseases, 135, 102-109. https://doi.org/10.1016/j.ijid.2023.02.021

Cox, L. M. (2021). Gut microbiota in health and disease. Nature Reviews Gastroenterology & Hepatology, 18(7), 493-506. https://doi.org/10.1038/s41575-021-00473-3

Cryan, J. F., & Dinan, T. G. (2017). Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nature Reviews Neuroscience, 18(11), 696-711. https://doi.org/10.1038/nrn.2017.103

Dantzer, R. (2020). Cytokine-induced depression: A potential therapeutic target for depression. Psychoneuroendocrinology, 111, 104471. https://doi.org/10.1016/j.psyneuen.2019.104471

Davis, C. D. (2020). The role of diet and nutrition in the gut microbiome. Frontiers in Nutrition, 7, 20. https://doi.org/10.3389/fnut.2020.00020

Dinan, T. G., & Cryan, J. F. (2019). Gut microbiota: a new perspective on the relationship between the gut and the brain. Journal of Psychopharmacology, 33(1), 42-55. https://doi.org/10.1177/0269881118781642

Hossain, S. (2022). Pro-inflammatory cytokine levels in malnourished children: A study from Bangladesh. Journal of Pediatric Nutrition, 19(2), 157-164. https://doi.org/10.1007/s12310-022-00428-y

Ikechukwu, A. (2022). Cytokine responses in acute malaria cases in Nigeria. African Journal of Infectious Diseases, 16(2), 110-118. https://doi.org/10.4314/ajid.v16i2.3

Kurniawan, M. (2023). Cytokine responses in dengue fever: Implications for treatment. Tropical Medicine and Infectious Disease, 8(3), 142. https://doi.org/10.3390/tropicalmed8030142

Mekonnen, T. (2023). Immune responses in malaria-endemic regions of Ethiopia. Malaria Journal, 22(1), 45. https://doi.org/10.1186/s12936-023-04578-1

Miyauchi, E. (2022). Probiotics and the microbiome in metabolic health. Nature Reviews Endocrinology, 18(4), 225-239. https://doi.org/10.1038/s41574-022-00566-3

Mochizuki, Y. (2022). Effects of chronic malnutrition on cytokine production in children. Nutrition Reviews, 80(3), 437-445. https://doi.org/10.1093/nutrit/nuaa085

Ngure, K. (2023). Cytokine profiles in HIV-positive individuals in Kenya. African Journal of Immunology, 32(2), 87-95. https://doi.org/10.4314/aji.v32i2.3

Njuguna, I. (2023). Immune markers in HIV-positive patients receiving antiretroviral therapy in Kenya. AIDS Research and Therapy, 20(1), 14. https://doi.org/10.1186/s12981-023-00417-7

Odeyemi, O. A. (2022). Urban pollution and cytokine response: A study in Nigeria. Environmental Science and Pollution Research, 29(14), 20645-20654. https://doi.org/10.1007/s11356-022-20143-4

Okafor, C. (2023). Inflammatory cytokines in HIV-positive individuals in Nigeria: Implications for health. Journal of Viral Hepatitis, 30(2), 213-220. https://doi.org/10.1111/jvh.13926

Pérez-Brocal, V. (2019). Gut microbiota diversity and its role in health and disease. Microbial Ecology in Health and Disease, 30(1), 1574. https://doi.org/10.1080/16512235.2019.1574

Rook, G. A. (2018). Hygiene, the immune system, and the evolution of the human microbiome. Nature Reviews Immunology, 18(1), 60-70. https://doi.org/10.1038/nri.2017.128

Sinha, S. (2021). Pro-inflammatory cytokines in tuberculosis: A comprehensive review. International Journal of Infectious Diseases, 103, 104-110. https://doi.org/10.1016/j.ijid.2020.10.016

Strachan, D. P. (1989). Hay fever, hygiene, and household size. BMJ, 299(6710), 1259-1260. https://doi.org/10.1136/bmj.299.6710.1259

Tiongson, J. (2023). Cytokine profiles in severe COVID-19 cases in the Philippines. International Journal of Infectious Diseases, 121, 45-52. https://doi.org/10.1016/j.ijid.2022.09.019

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Published

2024-10-24

How to Cite

Jian Choi. (2024). Influence of Gut Microbiota Diversity on Human Immune System Response in Korea. European Journal of Biology, 9(2), 22–33. https://doi.org/10.47672/ejb.2506

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